Significant elevation of leptin can be detected in AF 2 months earlier than the appearance of symptoms; thus, it may be used as a predictive marker for preeclampsia. The increase of these antiangiogenic proteins supports the roles of inflammation and oxidative stress in pathogenesis of preeclampsia...
So these weird soluble factor levels are also showing up in the amniotic fluid. Leptin in particular was high, which is related to the placenta's "hijacking" of the maternal metabolism.
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