by laura (5139 Posts), Fri Nov 28, 2003 02:27 pm
Alysa, I respect your right to not wish to take aspirin, and your right to talk about it, but I worry about women who are prescribed asprin by their doctors sitting around worrying about having an abruption. Aspirin does not cause hypertension, it is commonly used as a treatment for hypertension (of course, I have links to articles supporting this available upon request). And placental abruptions don't cause hypertension, they are caused by hypertension. (I wasn't clear on which factor you suggested caused hypertension) I found some information from a reputable source on the question.
"AHRQ is the Agency for Healthcare Research and QualityÃ¢â‚¬â€the Nation's lead Federal agency for research on health care quality, costs, outcomes, and patient safety."
This governmental agency looked at ALL of the research associated with low dose aspirin and came to some conclusions for doctors, and they can be found at this site:
Preeclampsia and Low-Dose Aspirin Therapy
Although findings from some clinical trials indicate that aspirin therapy is effective in reducing the risk of preeclampsia in pregnant women, other studies suggest that this therapy is associated with an increased risk of placental abruption. The PORT conducted several analyses to examine the data from these and other studies. The team's findings indicate that:
-There is an association with aspirin therapy compliance as measured by a maintained decrease in serum thromboxane levels, resulting in improved pregnancy outcomes such as less preeclampsia, less premature rupture of membranes, fewer preterm births, higher mean birthweight, and fewer small-for-gestational-age births.
-There appears to be no association between the risk of placental abruption and subsequent perinatal mortality and receiving preventive low-dose aspirin therapy. Biochemical Predictors of Preterm Birth PORT investigators, both in parallel and in collaboration with colleagues in NIH-funded studies examined biochemical markers or predictors of preterm birth. Findings from this work include:
Using data from serum samples of women in studies on risk factors for preterm delivery or term low birthweight, the PORT was able to conclude that the presence of interleukin-6 (IL-6) in the amniotic fluid is associated with an increase in spontaneous labor and may be useful as a predictor (or marker) for upper-genital-tract infection.
Other serum substances (e.g., plasma ferritin levels measured at 26 weeks' gestation) may be useful as predictors of spontaneous preterm birth.
Allie 5-13-98 (35 weeks-pre-e)
Baby Camille 4-17-03 (36 weeks- htn and oligo)