Toll-Like Receptor 3 Activation During Preg.

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Re : Toll-Like Receptor 3 Activation During Preg.

Postby blythe » Sat Oct 03, 2009 03:28 pm

I did a quick pubmed search - looks like there's a (small?) correlation, and this current study is looking at possible causal relationships?
Maternal infection and risk of preeclampsia: systematic review and metaanalysis.
...Urinary tract infection and periodontal disease during pregnancy are associated with an increased risk of preeclampsia. More studies are required to verify this as well as to explore whether or not such relationships are causal and, if so, the mechanisms involved.
Association between maternal infections and preeclampsia: a systematic review of epidemiologic studies.
CONCLUSIONS: In our analysis, any infection (bacterial or viral) was associated with a two-fold higher risk of preeclampsia. This association may provide a potential explanation for preeclampsia-related inflammation.

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Re : Toll-Like Receptor 3 Activation During Preg.

Postby catherine » Fri Oct 02, 2009 09:32 pm

Uh... yes I do, in a somewhat peripheral sense.

Um, the disconnect for me here is that TLR3 specifically recognizes double stranded RNA which only occurs in nature in the context of certain (but not all) viruses. The poly I:C administered to the animals in these experiments is a synthetic compound that mimics viral RNA. So immune cells that carry this receptor become activated when the viral ligand sticks to it. Hence the authors' comment that viral infection during pregnancy could trigger preeclampsia.

I'd have thought that someone somewhere has looked quite exhaustively by now for some evidence for an infectious cause or trigger for preeclampsia.....

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Toll-Like Receptor 3 Activation During Preg.

Postby caryn » Fri Oct 02, 2009 07:45 pm

These findings demonstrate that sustained maternal immune system activation via TLR3 during pregnancy causes PE-like symptoms in rats and suggest that viral infection during pregnancy may contribute to the development of PE.

Catherine works on this stuff. I think basically it's saying that anything that pisses off your immune system in pregnancy pisses off your immune system, and can therefore lead to preeclampsia, which is pretty much *defined* at this point as an ineluctably pissed-off immune system in pregnancy.

Hopefully Catherine will riff on this further. :-)

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