What happens biologically during Pre-E

This section is for discussions with other women who have probably been through the same signs/symptoms that you may be experiencing. Please note, we cannot offer medical advice and encourage members to discuss their concerns with their doctors. New members, come on in and introduce yourself!
ozierja
Registered User
Posts: 584
Joined: Wed Oct 04, 2006 11:08 am

Re : What happens biologically during Pre-E

Postby ozierja » Tue Nov 28, 2006 08:50 am

I really wish there was more research out there about this condition and treatments for it. Being around research in my job I can't understand why there is so much more research on diseases that are less common and certainly less damaging (at least potentially). I work at a major medical center/university in the top 20 of US research funding and not one study done here is for PE or PIH or HELLP.

lisainnj
Registered User
Posts: 595
Joined: Fri Sep 08, 2006 07:07 pm

Re : What happens biologically during Pre-E

Postby lisainnj » Mon Nov 27, 2006 08:43 pm

I would settle for my baby being blind and alive, sigh...

But researchers seem to be looking at hypoxia-reoxygenation as a cause of preeclampsia - apparently more damaging than simple hypoxia. And carbon monoxide (smokers have less risk) seems to limit the cellular damage caused by hypoxia-reoxygenation.

So giving the mother oxygen unless done very very gradually might be a bad idea.

ozierja
Registered User
Posts: 584
Joined: Wed Oct 04, 2006 11:08 am

Re : What happens biologically during Pre-E

Postby ozierja » Mon Nov 27, 2006 11:59 am

I think maybe a s-Flt1 inhibitor would be great thing to try to produce. There might be more adverse effects with too much oxygen. One of the premises behind retinopathy of prematurity research is that ROP develops because of the varying levels of oxygen, not just the hypoxic state. So when the sats of the preemie go down, the O2 gets turned up and when the sats are high, the O2 gets lowered. What ends up happening is that once the preemie is off O2 then the retinal vessels that grow but they are the leaky ones and not properly formed.

lisainnj
Registered User
Posts: 595
Joined: Fri Sep 08, 2006 07:07 pm

Re : What happens biologically during Pre-E

Postby lisainnj » Sun Nov 26, 2006 01:25 pm

I've been wondering, if the placenta is hypoxic, would boosting the mother's oxygen level help? Maybe the placenta could settle down some and stop producing so much s-Flt1? At least in some cases?

User avatar
misscoleyp
Registered User
Posts: 436
Joined: Thu Feb 16, 2006 05:49 pm
Location: North Texas

Re : What happens biologically during Pre-E

Postby misscoleyp » Sat Nov 25, 2006 03:47 pm

Can this thread get stickied and updated with any updates from current research? This thread would be great for those wanting a deeper understanding.

deerhart
Registered User
Posts: 3282
Joined: Thu Jan 30, 2003 08:54 am

Re : What happens biologically during Pre-E

Postby deerhart » Sat May 27, 2006 01:21 pm

Oh yes there is a strong corrolation between miscarriages and other problems, especially blood clots. In fact, most doctors you talk to will know the connection between blood clotting disorders and multiple miscarriages but not between it and PE (since a lot of woman with them end up with the miscarraiges instead of PE because they don't get that far along).

Having multiple miscarriages is enough reason to run a full set of blood work on both clotting and autoimmune issues.

As for post partem PE, well delivery isn't the only cure, time is as well. You could have clots in places other then the placenta (blood clots), there may be residual eneimes left over that your body is attacking (auto immune), hormones can still be out of whack (this can affect everything from clotting, autoimmune to toher conditions like PCOS, diabetes etc..).

Not only do you have to deliver, but you also have to have time pass for whatever is cuasing the PE in the first place to start to correct itself. For some it takes a matter of minutes, others it can take weeks and for some of us it can takes months or years for our bodies to come back to normal.

User avatar
caryn
Forum Moderator
Posts: 10178
Joined: Fri Jun 25, 2004 06:36 am

Re : What happens biologically during Pre-E

Postby caryn » Fri May 26, 2006 11:47 am

I think the theory there goes: during delivery, the placenta is quite hypoxic, because it's undergoing labor contractions that cut off its blood supply. So it dumps a bunch of sFlt-1 into your system. The only way for sFlt-1 to be removed from your system is for it to bind to VEGF, which inactivates it. So it rattles around your vascular system for a while, and your body keeps making VEGF, and eventually you've got enough VEGF to mop up all the sFlt-1, and *then* the VEGF your body's making can go to work plugging all the little holes in the vascular system.

So depending on how much got released, it takes some time for your body to begin to repair itself, and it can even experience further damage from the lack of repair postpartum.

Did that make any sense? [:D]

countrymom2e
Registered User
Posts: 134
Joined: Mon Nov 14, 2005 09:05 am

Re : What happens biologically during Pre-E

Postby countrymom2e » Thu May 25, 2006 11:07 pm

Great explanations! One question - how does post-partum pre-e factor in to things? I would think that once the placenta is delivered, the body should start to recover? But what about when things worsen post-partum?

kim
Registered User
Posts: 555
Joined: Sun Mar 30, 2003 08:44 pm

Re : What happens biologically during Pre-E

Postby kim » Wed May 24, 2006 06:53 pm

Thanks ladies!! I appreciate this thread!

hayesmama
Registered User
Posts: 151
Joined: Fri Dec 09, 2005 02:44 pm

Re : What happens biologically during Pre-E

Postby hayesmama » Wed May 24, 2006 01:45 pm

Excellent posts. This is great info! I need to get dh in here to read this. May even print this for the doc (keeping all sources anonymous of course). I never had pe/pih issues until after my molar pg---interesting.


Return to “Ask the Experienced”

Who is online

Users browsing this forum: No registered users and 3 guests