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by expert@preeclampsia.org
Sat Oct 23, 638945 11:53 pm
Forum: Ask the Experts
Topic: opinions on new _Nature_ article?
Replies: 8
Views: 12720

Re : opinions on new _Nature_ article?

<t>I think it is important to distinguish between physiologic stimulation of the renin angiotensin system, and excess, inappropriately suppressed angiotensin II; As we and many others have shown, normal pregnancy is characterized by vasodilation, and physiologic stimulation of the RAS - renin and An...
by expert@preeclampsia.org
Sat Oct 23, 638945 11:52 pm
Forum: Ask the Experts
Topic: opinions on new _Nature_ article?
Replies: 8
Views: 12720

Re : opinions on new _Nature_ article?

<t>It is unfortunate that investigators are now using the lay media to promote their interests. We have been through so many of these publications suggesting predction, cause of disease and possible treatment. The bad thing is that the most vulnerable patients are the most affected with these report...
by expert@preeclampsia.org
Sat Oct 23, 638945 11:50 pm
Forum: Ask the Experts
Topic: opinions on new _Nature_ article?
Replies: 8
Views: 12720

Re : opinions on new _Nature_ article?

I agree with *****. This is an interesting finding and perhaps has eventual implications perhaps even therapeutic for preeclampsia but very far from "ready for prime time"
by expert@preeclampsia.org
Sat Oct 23, 638945 11:48 pm
Forum: Ask the Experts
Topic: opinions on new _Nature_ article?
Replies: 8
Views: 12720

Re : opinions on new _Nature_ article?

<t>Agree with *****. Several times a year, a basic science paper is published that has some relevance to preeclampsia - but is hyped as "one step short of a cure." The logical step from this paper could be use of ACE-inhibitors with appropriate attention to fetal effects. <br/> <br/> We have some pu...
by expert@preeclampsia.org
Sat Oct 23, 638945 11:47 pm
Forum: Ask the Experts
Topic: opinions on new _Nature_ article?
Replies: 8
Views: 12720

Re : opinions on new _Nature_ article?

<t>I just received the article from my department and for those that do not have it it is attached. Worse than I thought for all the brouhaha. One 24 PE and 12 controls but only 10 dots on fig 4 with lots of overlap. Ironically oxidative effects are also raised in contols but they have lower BP in p...
by expert@preeclampsia.org
Sat Oct 23, 638945 11:45 pm
Forum: Ask the Experts
Topic: opinions on new _Nature_ article?
Replies: 8
Views: 12720

Re : opinions on new _Nature_ article?

Here is my take on the paper: I found the paper quite interesting. The authors have identified that angiotensinogen cleavage by renin is redox dependent and argue that oxidative stress may be responsible for angiotensin I release (locally at sites of oxidative damage), that may have detrimental cons...
by expert@preeclampsia.org
Sat Oct 23, 638945 11:42 pm
Forum: Ask the Experts
Topic: opinions on new _Nature_ article?
Replies: 8
Views: 12720

Re : opinions on new _Nature_ article?

<t>The actual role of angiotensin in preeclampsia in the pathophysiology has gone around in circles for years. Also this write up is atrocious and reminds me of the recent marketing of the press of the metabalomics The circumspect me is always annoyed by these approaches which unfortunately get much...
by expert@preeclampsia.org
Sat Oct 23, 638945 11:40 pm
Forum: Ask the Experts
Topic: opinions on new _Nature_ article?
Replies: 8
Views: 12720

opinions on new _Nature_ article?

The article on angiotensinogen is being covered broadly in the popular press as "scientists discover cause of preeclampsia" with cure to follow shortly. Could I get some Expert commentary on the significance of this finding? (We have a preliminary discussion going here -- I'm happy to be corrected i...
by expert@preeclampsia.org
Thu Aug 23, 638942 7:02 am
Forum: Ask the Experts
Topic: current thinking on low-dose aspirin (LDA)?
Replies: 9
Views: 14212

Re : current thinking on low-dose aspirin (LDA)?

<t>The dept librarian is back and I finally was able to get the whole article. Recall I had noted my surprise, and they did write a good article applying those very sophisticated tools of both statistics and metanalysis jargon. Also their discussion was appropriately circumspect (in contradistinctio...
by expert@preeclampsia.org
Thu Aug 23, 638942 6:57 am
Forum: Ask the Experts
Topic: current thinking on low-dose aspirin (LDA)?
Replies: 9
Views: 14212

Re : current thinking on low-dose aspirin (LDA)?

<t>This is news to me. I thought all that was settled years ago and the NIH data was made available to *****, or at least was promised. I remember some final chats with everyone happy. But then again, wishful thinking can lead to twisted memories!!!(that is I had thought I had done some groundwork o...

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