Search found 322 matches

by expert@preeclampsia.org
Thu Aug 23, 638942 6:53 am
Forum: Ask the Experts
Topic: current thinking on low-dose aspirin (LDA)?
Replies: 9
Views: 14216

Re : current thinking on low-dose aspirin (LDA)?

<t>While I almost agree with the totality of your comments, the Paris collaboration would have been definitive had the NICHD data been shared - in my humble (non-US)) opinion, it would have been a better use of US tax dollars to have included those data in an individual patient meta-analysis as the ...
by expert@preeclampsia.org
Thu Aug 23, 638942 6:52 am
Forum: Ask the Experts
Topic: current thinking on low-dose aspirin (LDA)?
Replies: 9
Views: 14216

Re : current thinking on low-dose aspirin (LDA)?

<t>I agree with *****, *****, ***** about metaanalysis. So far, at least 25 different metaanalysis and systematic reviews were written about low dose aspirin. The one by the Paris collaborative showed a reduction of 10%. The most recent one in the Green Journal does not have any new information, and...
by expert@preeclampsia.org
Thu Aug 23, 638942 6:47 am
Forum: Ask the Experts
Topic: current thinking on low-dose aspirin (LDA)?
Replies: 9
Views: 14216

Re : current thinking on low-dose aspirin (LDA)?

Even in high risk groups (except for the "diagnosis") the expected incidences for the outcomes to be decreased to those "not so bad NNTs" where I might prescribe ASA, are usually not present (except for the diagnosis PE, but not for the adverse outcomes). On the other hand the incidence for side aff...
by expert@preeclampsia.org
Thu Aug 23, 638942 6:44 am
Forum: Ask the Experts
Topic: current thinking on low-dose aspirin (LDA)?
Replies: 9
Views: 14216

Re : current thinking on low-dose aspirin (LDA)?

<t>I do not completely agree with the others. I do agree that metanalysis are problematic. Although, individual patient metanalysis (as was done in the PARIS study, and which I think must be what is being cited ( Askie LM, Duley L, Henderson-Smart DJ, Stewart LA, Group PC. Antiplatelet agents for pr...
by expert@preeclampsia.org
Thu Aug 23, 638942 6:42 am
Forum: Ask the Experts
Topic: current thinking on low-dose aspirin (LDA)?
Replies: 9
Views: 14216

Re : current thinking on low-dose aspirin (LDA)?

<t>Agree with ***** and *****. Great examples are the meta-analyses on Calcium (Br J Obstet Gynaecol 1994, JAMA, 1996) both suggesting very large benefits of Ca++ supplementation. Then comes CPEP (NEJM 1997) and no difference. Despite CPEP Ca++ remains in the Cochrane reviews as effective for preven...
by expert@preeclampsia.org
Thu Aug 23, 638942 6:40 am
Forum: Ask the Experts
Topic: current thinking on low-dose aspirin (LDA)?
Replies: 9
Views: 14216

Re : current thinking on low-dose aspirin (LDA)?

<t>There are a substantial number of large, well designed clinical trials for the prevention of preeclampsia with ASA. While all suggest some trend towards a positive effect on the diagnosis of preeclampsia, the effect size is very small. At least one has a strong suggestion of an increased risk for...
by expert@preeclampsia.org
Thu Aug 23, 638942 6:38 am
Forum: Ask the Experts
Topic: current thinking on low-dose aspirin (LDA)?
Replies: 9
Views: 14216

Re : current thinking on low-dose aspirin (LDA)?

<t>To date I still remain less than impressed, as these meta analyses have had to look at ~35,000 patients , the number to treat to avoid any real outcome problems are large, and there is reference that the effect is only in a high risk subgroup yet to be identified. <br/> <br/> A final remark; all ...
by expert@preeclampsia.org
Thu Aug 23, 638942 6:35 am
Forum: Ask the Experts
Topic: current thinking on low-dose aspirin (LDA)?
Replies: 9
Views: 14216

current thinking on low-dose aspirin (LDA)?

Can I get some new Expert commentary on the value of daily baby aspirin for women with a history of PE?
by expert@preeclampsia.org
Fri Sep 07, 638936 5:05 pm
Forum: Ask the Experts
Topic: preeclampsia, sinus exit block, family history
Replies: 1
Views: 8335

Re : preeclampsia, sinus exit block, family history

<t>Her risk for recurrence are low but still more than the risk for a first pregnancy without history of preeclampsia. Best guess would be 10 to 20% compared to 4-6% with a first pregnancy. The good news is that in the next pregnancy if the preeclampsia does recur it is usually a little later and a ...
by expert@preeclampsia.org
Fri Sep 07, 638936 5:04 pm
Forum: Ask the Experts
Topic: preeclampsia, sinus exit block, family history
Replies: 1
Views: 8335

preeclampsia, sinus exit block, family history

<t>With my first child (third pregnancy), it was discovered that I had preeclampsia when I was 36 weeks pregnant at a regular OB check-up (my BP was through the roof, protein in urine, severely swollen, gained 11lbs in a week due to water gain). I was induced immediately, and via a successful c-sect...

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