by caryn (10159 Posts), Sun Jan 04, 2009 01:26 pm
I can only find about 10 papers on this in PubMed, most of them older. That's *probably* because the scientific consensus decided (because of some other research) that preeclampsia isn't a typical immune response involving histamines, but a specific way in which the "induction tolerance" of a foreign placenta goes wrong. They call it a "novel form of allorecognition", or something like that, but the idea is that it involves some cells that just do placentation and not anything else.
Here's a [url="http://www.ncbi.nlm.nih.gov/pubmed/12369286"]more recent review[/url] (I don't know the journal) that says The participation of mast cells and histamine in blastocyst implantation is very controversial. In W/Wv mice (without mast cells) normal implantation was observed. It denies the main role of mast cells in this process but dos not exclude histamine action...
And I'm afraid that's all I know about it. I'd ask your MFM!