Expressions of vitamin D metabolic component in placenta

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Expressions of vitamin D metabolic component in placenta

Postby caryn » Thu Aug 09, 2012 07:38 am

These results provide a direct evidence of disrupted vitamin D metabolic homeostasis in the preeclamptic placenta...

http://www.ncbi.nlm.nih.gov/pubmed/22871339

So that bit in the abstract where they talk about genes and upregulating and downregulating? What that means in practical terms is this: so far as the studies show now, we go into pregnancy with a normal distribution of vitamin D (we look just like everyone else) and then as the placenta develops, it begins to sequester vitamin D, probably because doing so turns down some maternal immune system responses, which helps the placenta to hide from us.

The stuff about binding protein sites just means that the placenta is producing extra of a chemical that locks up vitamin D so that it's not bioavailable any more. This is probably why supplementing D doesn't seem to help - the placenta would just respond to a change in the concentration of vitamin D in the bloodstream by making more binding protein.
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
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Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy
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