Vasopressin: The Missing Link for Preeclampsia?

The Preeclampsia Foundation does not necessarily endorse any research or news found in this forum, we just want to share what is out there. Please use your own discretion to evaluate any information you find here.
User avatar
Forum Moderator
Posts: 10203
Joined: Thu Feb 16, 637032 6:26 pm

Vasopressin: The Missing Link for Preeclampsia?

Postby caryn » Fri Nov 07, 640510 8:45 pm

"Various lines of evidence support a "tissue rejection" type reaction toward the placenta as the primary initiating event in the development of preeclampsia, followed by a complex interplay among immune, vascular, renal, and angiogenic mechanisms that have been implicated in the pathogenesis of preeclampsia beginning around the end of the first trimester. Critically, it remains unclear what mechanism links the initiating event and these pathogenic mechanisms."

So, in mice, injecting arginine vasopressin creates preeclampsia symptoms - which might mean it's one of the triggers of preeclampsia symptoms in humans. If we could block the activity of triggers of the symptoms, at least some pregnancies could be sustained for longer. Blocking these triggers wouldn't implant the placenta better, so there are cases that wouldn't be helped by this, but anything that allows docs to block or delay the onset of symptoms would likely allow many preeclamptic pregnancies to last longer. I'll take "days not in NICU" and "time for steroids", so I hope this is supported in followup research!
Science! The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies?
A chance to participate in research? For us on Facebook or Twitter?

Caryn, @carynjrogers, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE
DD Bridget born by C-section after water broke at 39 weeks after a healthy pregnancy

Return to “Announcements and Preeclampsia in the News”

Who is online

Users browsing this forum: No registered users and 2 guests