Our Research Results

Working collaboratively with researchers to answer science's most pressing questions about preeclampsia

Last Updated on September 05, 2023

We are working to help research move forward to better understand how to diagnose, treat, and eventually prevent the poor outcomes preeclampsia can have on patients and their families. Learn more about the actions we've taken and the results we've discovered.

Last Updated on October 01, 2023

The Sisterhood Study piloted low-touch, remote recruitment strategies that relied on women with a history of preeclampsia to share study information with family and friends. It aimed to enroll 150 women with a FH of HDP and 150 controls.

Last Updated on August 11, 2023

Our data revealed massive dysregulation of gene expression in all cell classes that was almost exclusive to early preeclampsia.

Last Updated on October 03, 2020

Ellen W. Seely, MD,1,2 Ann C. Celi, MD, MPH,2,3 Jaimie Chausmer, FNP-C,4 Cornelia Graves, MD,5 Sarah Kilpatrick, MD, PhD,6 Jacinda M. Nicklas, MD, MPH,7 Mary L. Rosser, MD, PhD,8 Kathryn M. Rexrode, MD, MPH,2,9 Jennifer J. Stuart, ScD,2,9,10 Eleni Tsigas, BA,11 Jennifer Voelker, MS,11 Carolyn Zelop, MD,12,13 and Janet W. Rich-Edwards, ScD, MPH2,9,10

Last Updated on April 28, 2020

Mayri Sagady Leslie, Linda Briggs, Maritza Dowling, Jeongyoung Park - Vision Grant 2017

Last Updated on August 20, 2019

Edwards J, Stuart J, Skurnik G, Roche A, Tsigas E, Fitzmaurice G, Wilkins-Hauge L, Levkoff S, Seely E. Journal of Woman's Health. 2019

Last Updated on June 12, 2019

The Preeclampsia Foundation - Position Paper

Last Updated on July 09, 2018

Gammill H, Chettier R, Brewer A, Roberts J, Shree R, Tsigas E, & Ward K. Circulation

Last Updated on July 09, 2017

Tsigas, E. Obstetric Medicine.

Last Updated on June 16, 2016

Staff AC, Redman C, Williams D, Leeson P, Moe K, Thilaganathan B, Magnus P, Steegers E, Tsigas E, Ness R, Myatt L, Poston L, Roberts J. Hypertension. 2016.

Last Updated on June 15, 2016

Skurnik G, Roche A, Stuart J, Rich-Edwards J, Tsigas E, Levkoff S, Seely E. Hypertension in Pregnancy. 2016.

Last Updated on January 14, 2014

Souza, J, Widmer, M, Gulmezoglu, AM, Lawrie, T, Adejuyigbe, EA, Guillermo, C et al. Reproductive Health 2014, 11:61

Last Updated on December 21, 2013

Seely WE, Rich-Edwards J, Lui J, Nicklas MJ, Saxena A, Tsigas E, Levkoff ES. BMC Pregnancy and Childbirth. 2013,13:240

Last Updated on January 16, 2013

Postma IR, Groen H, Easterling TR, Tsigas EZ, Wilson ML, Porcel J, Zeeman GG. Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health 3 (2013) 227–234

Last Updated on January 16, 2013

Porcel J, Feigal C, Poye L, Postma IR, Zeeman GG, Olowoyeye A, Tsigas E, Wilson M. Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health 3 (2013) 254–260.

Last Updated on January 16, 2013

Von Dadelszen P, Sawchuck D, Hofmeyr GJ, Magee, LA, Bracken H, Mathai M, Tsigas EZ, Teela KC, Donnay F, Roberts JM. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. Volume 3, Issue 4 , Pages 199-202, October 2013.

Last Updated on January 16, 2013

Wallis, A; Tsigas, E; Saftlas, A; Sibai, B. J Matern Fetal Neonatal Med. 2013 Nov;26(16):1565-7.

Last Updated on January 16, 2013

Obstet Gynecol. 2013 Nov;122(5):1122-31. doi: 10.1097/01.AOG.0000437382.03963.88.

Last Updated on January 16, 2012

You WB1, Wolf MS, Bailey SC, Grobman WA. Am J Obstet Gynecol. 2012 May;206(5):431.e1-5. doi: 10.1016/j.ajog.2012.03.006. Epub 2012 Mar 13.

Last Updated on January 16, 2011

Von Dadelszen P, Payne B, Li J, Ansermino JM, Broughton Pipkin F, Côté AM, Douglas MJ, Gruslin A, Hutcheon JA, Joseph KS, Kyle PM, Lee T, Loughna P, Menzies JM, Merialdi M, Millman AL, Moore MP, Moutquin JM, Ouellet AB, Smith GN, Walker JJ, Walley KR, Walters BN, Widmer M, Lee SK, Russell JA, Magee LA; PIERS Study Group (Tsigas E, contributor).Lancet. 2011 Jan 15;377(9761):219-27. doi: 10.1016/S0140-6736(10)61351-7. Epub 2010 Dec 23.

Last Updated on January 16, 2011

Kozic JR, Benton SJ, Hutcheon JA, Payne BA, Magee LA, von Dadelszen P; Mark Ansermino J, Côté AM, Cundiff G, Gruslin A, Hugo D, Joseph KS, Lee SK, Li J, Lott P, Menzies J, Moutquin JM, Ouellet AB, Russell JA, Shaw D, Smith GN, Keith D, Tawagi G, Wagner B, Walters BN, Mahajan S, Noovao A, Kyle PM, Moore MP, Hall D, Wilhelm Steyn D, Biryabarema C, Mirembe F, Nakimuli A, Broughton Pipkin F, Loughna P, Walker JJ, Grobman W, Tsigas E, Merialdi M, Widmer M. J Obstet Gynaecol Can. 2011 Oct;33(10):995-1004.

Last Updated on January 16, 2011

(book chapter) Tsigas E, Magee L. Best Practice & Research Clinical Obstetrics & Gynecology 25 (2011), pp. 523-536 DOI information: 10.1016/j.bpobgyn.2011.03.001

Last Updated on January 16, 2007

Ilekis JV, Reddy U, Roberts JM and contributors. Reproductive Sciences 2007; 14; 508.

Last Updated on March 10, 2023

Hypertensive disorders of pregnancy (HDPs) are a risk factor for future cardiovascular disease; therefore, follow-up and implementation of early interventions is recommended. We performed a qualitative study to assess the feasibility and user response to a mobile-health tool and virtual consultation aimed at educating people with an HDP on future cardiovascular risk, and at better understanding patients’ priorities for postpartum care.

Last Updated on April 01, 2024

In this validation study of U.S. women, the majority accurately self-reported their preeclampsia diagnosis based on medical record review. A higher proportion of self-reports validated by clinician diagnosis than ACOG criteria, suggesting women remember the diagnosis given by their provider and providers may not always follow or document criteria when making a diagnosis.

Last Updated on January 25, 2024

Using a large insurance-based database, we did not observe a decreased risk of preeclampsia associated with HCQ treatment in pregnancy, although we cannot rule out residual and unmeasured confounding and misclassification. Further studies leveraging large population-based data and prospective collection could characterize how HCQ influences preeclampsia risk in pregnant patients with SLE and among persons at greater risk of hypertensive disorders of pregnancy.

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